EFFICACY AND SAFETY OF RADOTINIB IN CHRONIC PHASE CHRONIC MYELOID LEUKEMIA PATIENTS WITH RESISTANCE OR INTOLERANCE TO BCR-ABL1 TYROSINE KINASE INHIBITORS

Radotinib (IY5511HCL), a novel and selective BCR-ABL1 tyrosine kinase inhibitor, has shown pre-clinical le emt multitool 2.0 and phase I activity and safety in chronic myeloid leukemia.This phase II study investigated the efficacy and safety of radotinib in Philadelphia chromosome-positive chronic phase-chronic myeloid leukemia patients with resist

Early-stage laryngeal cancer (T1-T2) is commonly treated with organ-preserving techniques such as transoral laser microsurgery (TOLMS) or radiation therapy (RT), both providing comparable oncological outcomes but differing in functional results.Local recurrence occurs in approximately 10% of kicker pro comp 10 cases, making salvage surgery a crucia

Small cell lung cancer metastasizing to the parotid gland is very rare and only a auto rosvin few cases have been reported.A 64-year-old man presented with a painless mass and peripheral facial paralysis.Neck ultrasound identified a solid mass in the right parotid gland with enlargement of the lymph nodes in the gland and the right submandibular ly